SettingsModifier:Win32/PossibleHostsFileHijack is a harmful computer virus that should be removed from your system as soon as possible, otherwise, you may suffer quite a lot of computer issues as time go by. Once SettingsModifier:Win32/PossibleHostsFileHijack is executing, it may disable firewall settings and block other useful software in the infected PC which may allow other kinds of computer viruses like spyware, malware and browser hijacker to invade into the compromised PC much more easily.